New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
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چکیده
منابع مشابه
Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold
BACKGROUND The xanthine structure has proved to be an important scaffold in the process of developing a wide variety of biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved in the progression of diabetes mellitus and its complications. Therefore, the deve...
متن کاملAnalgesic activity of new synthetic thiazolidine-4-ones derivatives.
Ten new synthetic thiazolidine-4-ones derivatives (5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones) having different substituents at R1, R2 and R3 were evaluated for their analgesic activity using different animal models and their structure activity relationship was also elucidated. Chlorothiazolidine-4-ones and methoxythiazolidine-4-ones exhibited anal...
متن کاملNew Thiazolidine-4-ones of Ferulic Acid with Antioxidant Potential
New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (H-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluate...
متن کاملSynthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid.
New thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid (ibuprofen) have been synthesized as potential anti-inflammatory drugs. The structure of the new compounds was proved using spectral methods (FR-IR, 1H-NMR, 13C-NMR, MS). The in vitro antioxidant potential of the synthesized compounds was evaluated according to the total antioxidant activity, the DPPH and ABTS radical scav...
متن کاملDevelopment and optimization of the synthesis of new thiazolidin-4-one derivatives of ibuprofen.
UNLABELLED Ibuprofen, an important nonsteroidal anti-inflammatory agent, is one of the most prescribed drugs for the treatment of pain and inflammation from various rheumatic diseases, but some side effects can occur on long-term use. AIM The method for synthesis optimization of new derivatives of Ibuprofen with thiazolidin-4-one moiety, with improved pharmacological and toxicological profile...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2021
ISSN: 2050-6511
DOI: 10.1186/s40360-021-00475-0